Diabetic nephropathy is one of the important micro vascular complications of diabetes mellitus. In this study, effect of chebulic acid (CA) isolated from Terminalia chebula was evaluated on renal ischemia and reperfusion in diabetic rat models. Streptozotocin (50 mg/kg) and ischemia (30 min) alleviated various metabolic and nephropathy parameters. CA (25 mg/kg) effectively reduced the blood and urine glucose, serum and urine creatinine, blood and urine urea nitrogen, glycosylated hemoglobulin, proteinuria, urine albumin excretion, glomerular filtration rate (GFR) and increased serum insulin and glycogen level. CA also restored glucose 6 phosphate dehydrogenase (G6PDH), glutathione (GSH), superoxide dismutase (SOD), catalase and malondialdehyde (MDA) levels. Improvement in kidney and pancreas was also noted in histopathological studies. These results suggest that CA at dose of 25 mg/kg attenuate diabetic nephropathy in rats.
Loading....